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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Electrospun membranes are crucial for biomedical applications.
  • Controlling nanoscale structure is key for advanced material functions.
  • Lipid nanoparticles offer unique self-assembly properties.

Purpose of the Study:

  • To design and investigate a hybrid electrospun membrane with nanoscale structural hierarchy.
  • To explore the controlled functions of embedded lipid nanoparticles within the membrane.
  • To assess the material's response to environmental stimuli and external strain for biomedical applications.

Main Methods:

  • Hybrid membrane fabrication via electrospinning.
  • Characterization of lipid nanoparticle structure using small-angle X-ray scattering (SAXS) and electron microscopy.
  • In situ SAXS to study phase transitions in response to aqueous media.
  • Analysis of morphological and anisotropic responses under mechanical strain.

Main Results:

  • Internally self-assembled lipid nanoparticles (ISAsomes) embedded in a nanofibrous polymer network.
  • ISAsomes exhibit reversible phase transitions from bicontinuous inverse cubic (cubosomes) in solution to crystalline lamellar within the membrane.
  • Membrane contact with aqueous media triggers cubosome release upon nanofiber dissolution.
  • Anisotropic structural alignment observed at micro- and nanoscale levels under strain.

Conclusions:

  • The hybrid membrane design enables controlled nanoscale structural hierarchy.
  • Reversible phase transitions and triggered release offer tunable functionalities.
  • The material's response to strain provides strategies for biointerface engineering.
  • This work presents new avenues for advanced electrospun nanofibers in drug delivery and biointerfacing.