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Cell surface effects of human immunodeficiency virus.
R F Garry1, A A Gottlieb, K P Zuckerman
1Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana.
Bioscience Reports
|February 1, 1988
Summary
Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS) through cell killing via cell-cell fusion and single-cell death. Understanding HIV
Area of Science:
- Virology
- Immunology
- Cell Biology
Background:
- Cell killing by human immunodeficiency virus (HIV) contributes to acquired immunodeficiency syndrome (AIDS) pathogenesis.
- HIV infection in cultured cells exhibits two primary cytopathological effects: cell-cell fusion and single-cell killing.
- Both observed cytopathic effects are linked to cell surface interactions involving HIV.
Purpose of the Study:
- To propose a model for HIV-mediated cell surface processes.
- To define the roles of viral envelope and cell surface molecules in HIV-induced cell killing.
- To identify mechanisms for establishing persistently infected cells.
Main Methods:
- The study proposes a theoretical model based on existing knowledge of HIV-cell interactions.
- The model focuses on cell surface events and molecular interactions.
- No experimental data generation is described; it's a conceptual framework.
Main Results:
- The proposed model outlines potential pathways for HIV-mediated cell-cell fusion.
- The model describes mechanisms for HIV-induced single-cell killing.
- It highlights the significance of viral and cellular surface molecules in these processes.
Conclusions:
- Elucidating HIV's cell surface effects is crucial for understanding AIDS pathogenesis.
- The model provides a framework for investigating HIV-induced cell death.
- Insights may guide the development of targeted antiviral therapies selective for HIV-infected cells.