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Updated: Dec 8, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
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Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

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Macrocycles and Supramolecules as Antioxidants: Excellent Scaffolds for Development of Potential Therapeutic Agents

Jung-Seop Lee1, In-Ho Song1, Pramod B Shinde2

  • 1Institute of Applied Chemistry and Department of Chemistry, Hallym University, Chuncheon 200702, Korea.

Antioxidants (Basel, Switzerland)
|September 17, 2020
PubMed

Insights

Synthetic antioxidants derived from supramolecular scaffolds show promise for combating oxidative stress and inflammation. These novel compounds offer potential therapeutic benefits against diseases linked to reactive oxygen species (ROS).

Area of Science:

  • Supramolecular Chemistry
  • Medicinal Chemistry
  • Biochemistry

Background:

  • Oxidative stress from reactive oxygen species (ROS) damages biomolecules, leading to acute inflammation.
  • Unresolved acute inflammation can progress to chronic inflammation and diseases like cancer and cardiovascular conditions.
  • While natural antioxidants are studied, synthetic options offer vast potential for pharmacological applications.

Purpose of the Study:

  • To explore the design and development of novel synthetic antioxidants.
  • To investigate supramolecular scaffolds for antioxidant drug discovery.
  • To focus on modulating biochemical processes related to ROS and oxidative stress.

Main Methods:

  • Reviewing interdisciplinary approaches in synthetic antioxidant development.
  • Examining supramolecular scaffolds like calixarenes, resorcinarenes, and porphyrins.
  • Assessing the free radical scavenging abilities of supramolecular derivatives.

Main Results:

  • Supramolecular chemistry provides versatile scaffolds for creating novel antioxidants.
  • Derivatives of calix[n]arene, resorcinarene, and porphyrins show potential in scavenging free radicals.
  • These synthetic antioxidants can modulate free radical reactions.

Conclusions:

  • Novel synthetic antioxidants based on supramolecular scaffolds are promising for therapeutic use.
  • These compounds offer a strategy to combat disorders related to oxidative stress.
  • Further development holds potential for treating oxidative stress-induced diseases.
Keywords:
antioxidantcalix[n]arenecalixpyrrolecalixtyrosolcucurbit[n]uriloxidative stressporphyrinradical scavengerreactive nitrogen speciesreactive oxygen speciesresorcinarenesupramolecules

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