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Updated: Dec 8, 2025

Assessment and Communication for People with Disorders of Consciousness
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Lessons from the CONSCIOUS-1 Study.

Alexander J Schupper1, Matthew E Eagles2, Sean N Neifert1

  • 1Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Journal of Clinical Medicine
|September 17, 2020
PubMed
Summary
This summary is machine-generated.

Clazosentan reduced moderate to severe angiographic vasospasm in aneurysmal subarachnoid hemorrhage (aSAH) patients. While not statistically significant for outcomes, post-hoc analyses offer insights into aSAH management.

Keywords:
angiographic vasospasmcerebral aneurysmcerebral infarctiondelayed cerebral ischemiamanagementsubarachnoid hemorrhage

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Area of Science:

  • Neurology
  • Neurosurgery
  • Clinical Trials

Background:

  • Aneurysmal subarachnoid hemorrhage (aSAH) treatment has seen improved outcomes despite limited efficacious therapies.
  • The reasons for these improved outcomes in aSAH management remain unclear.

Purpose of the Study:

  • To analyze the Clazosentan to Overcome Neurological Ischemia and Infarction Occurring After Subarachnoid Hemorrhage (CONSCIOUS-1) trial data.
  • To investigate the effect of clazosentan on angiographic vasospasm (aVSP) in aSAH patients.

Main Methods:

  • Phase-2 randomized clinical trial involving approximately 400 patients with aSAH.
  • Assessment of clazosentan's efficacy on moderate to severe angiographic vasospasm.
  • Utilization of detailed, rigorously collected data for post-hoc analyses.

Main Results:

  • Clazosentan demonstrated a reduction in moderate to severe angiographic vasospasm.
  • No statistically significant effect on the extended Glasgow outcome score (GOS) was observed, as the study was not powered for this endpoint.

Conclusions:

  • Post-hoc analyses of the CONSCIOUS-1 trial provide expanded knowledge on aSAH management.
  • Clazosentan shows potential in mitigating angiographic vasospasm following aSAH.