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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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[Laparoschisis. Hypotrophy and intestinal lesions].

E Sapin1, J Y Kurzenne, F Bargy

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Summary

Infants with gastroschisis often have low birth weights, suggesting a link between altered fetal growth and the condition. Amniotic fluid may influence fetal development in gastroschisis cases.

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Area of Science:

  • Neonatal surgery
  • Pediatric surgery
  • Fetal development

Context:

  • Study analyzed 37 gastroschisis cases from 1983-1987.
  • Compared gastroschisis infants with omphalocele and intestinal atresia cases.
  • Investigated fetal growth patterns in abdominal wall defects.

Purpose:

  • To compare birth weights of gastroschisis neonates with other congenital anomalies.
  • To explore potential factors influencing fetal growth retardation in gastroschisis.

Summary:

  • Gastroschisis cases frequently presented with low birth weights (70% below 10th percentile), more so than prematurity by gestation (40%).
  • Birth weight comparisons indicated similarities between gastroschisis and neonates with omphaloceles or upper intestinal atresia.
  • Authors propose amniotic fluid's role in fetal growth, with herniated bowel alterations potentially causing growth retardation in gastroschisis.

Impact:

  • Highlights the significant issue of fetal growth retardation in gastroschisis.
  • Suggests a potential etiological link involving amniotic fluid and bowel development.
  • Provides comparative data for understanding abdominal wall defects and associated growth issues.