Long-Term Inhalative Sedation in Children With Pulmonary Diseases

Related Experiment Video

Updated: Dec 8, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

3.0K

Jochen Meyburg1, David Frommhold2,3, Johann Motsch4

  • 1Department of General Pediatrics, University Children's Hospital, Heidelberg, Germany.

Journal of Intensive Care Medicine
|September 17, 2020
PubMed

Insights

Long-term inhalative sedation (LTIS) is safe and feasible in children, even those with severe lung disease. This approach may allow faster reduction of other sedatives, but close monitoring for side effects is essential.

Area of Science:

  • Pediatric Intensive Care
  • Respiratory Medicine
  • Anesthesiology

Background:

  • Recent studies suggest beneficial effects of long-term inhalative sedation (LTIS) in adult patients with acute respiratory distress syndrome (ARDS).
  • LTIS offers a potential alternative for sedation in critically ill patients.

Purpose of the Study:

  • To evaluate the safety and feasibility of LTIS in children with severe respiratory diseases.
  • To compare LTIS outcomes in children with lung disease versus those with normal lung function.
  • To explore the potential of LTIS for pediatric patients with ARDS.

Main Methods:

  • Single-center retrospective study.
  • Analysis of 37 LTIS courses in 29 pediatric intensive care unit (PICU) patients (July 2011-July 2019).
  • Utilized the AnaConDa® device for LTIS administration.

Main Results:

  • LTIS was feasible in all pediatric patients, including those with severe lung impairment.
  • Concomitant intravenous sedatives were reduced more rapidly in children with lung diseases.
  • Cardiocirculatory depression occurred in all patients, but severe side effects were rare.

Conclusions:

  • LTIS is a feasible sedation method for children, even with significant respiratory compromise.
  • A prospective trial investigating LTIS for pediatric ARDS is warranted.
  • Close monitoring of cardiocirculatory function during LTIS is crucial.
Abstract

Keywords:
ARDSAnaConDa®PICUanestheticsinhalative sedationisoflurane

More Related Videos

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells04:56

In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells

Published on: October 23, 2018

6.9K
Guidelines for Elective Pediatric Fiberoptic Intubation11:19

Guidelines for Elective Pediatric Fiberoptic Intubation

Published on: January 17, 2011

18.1K

Related Concept Videos

Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
757
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
466
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
598
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.2K
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
778
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
882