Related Experiment Video
Updated: Dec 8, 2025
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Developing the novel bioinformatics algorithms to systematically investigate the connections among survival time, key
Yujie You1, Xufang Ru2, Wanjing Lei1
1College of Computer Science, Sichuan University, Chengdu, 610065, China.
Background:
Glioblastoma multiforme (GBM) is one of the most common malignant brain tumors and its average survival time is less than 1 year after diagnosis.
Results:
Firstly, this study aims to develop the novel survival analysis algorithms to explore the key genes and proteins related to GBM. Then, we explore the significant correlation between AEBP1 upregulation and increased EGFR expression in primary glioma, and employ a glioma cell line LN229 to identify relevant proteins and molecular pathways through protein network analysis. Finally, we identify that AEBP1 exerts its tumor-promoting effects by mainly activating mTOR pathway in Glioma.
Conclusions:
We summarize the whole process of the experiment and discuss how to expand our experiment in the future.
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