[Submicroscopic features of guanylate cyclase detection in mammalian epithelial and myocardial cells]

The electron cytochemical method of guanylate cyclase demonstrated a number of advantages making possible differentiation between the plasmalemmal, cytoplasmic, nucleoplasmic, and nucleolar localization of the enzyme. This method permitted to reveal that the enzyme possessed organ specificity of distribution in the cell and could be activated by a specific activator--sodium azide. The distribution of guanylate cyclase strictly correlated with the functional state of the cell.