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Association of vitamin D gene polymorphisms in children with asthma - A systematic review

Narmada Ashok1,2, Richard Kirubakaran3, Radha Saraswathy4

  • 1School of Biosciences & Technology, VIT University, Vellore.

Heliyon
|September 17, 2020
PubMed

Insights

Vitamin D gene variations are linked to childhood asthma. Specific polymorphisms in Vitamin D Receptor (VDR) and metabolic genes show significant associations, influencing asthma risk in children.

Area of Science:

  • Genetics and immunology
  • Pediatric respiratory diseases
  • Nutritional genomics

Background:

  • The link between Vitamin D and childhood asthma is established.
  • Individual studies have explored Vitamin D gene polymorphisms.
  • A comprehensive systematic review on these polymorphisms in pediatric asthma is lacking.

Purpose of the Study:

  • To systematically review and meta-analyze the association between Vitamin D-associated gene polymorphisms and asthma in children (0-18 years).
  • To identify specific gene variants that may confer risk or protection against childhood asthma.

Main Methods:

  • Systematic review and meta-analysis of 20 full-text articles.
  • Included 15 case-control studies and 5 family-based linkage disequilibrium studies.
  • Analyzed data from 2491 cases and 3682 controls, with quantitative and qualitative approaches.

Main Results:

  • Significant protective associations found for Apa1 and Taq1 polymorphisms.
  • Increased asthma odds linked to Apa1, Bsm1, Fok1, and Taq1 polymorphisms.
  • Ethnic variations observed; qualitative analysis also revealed significant associations.

Conclusions:

  • Significant associations exist between Vitamin D Receptor (VDR) polymorphisms (Apa1, Bsm1, Fok1, Taq1) and childhood asthma.
  • Polymorphisms in Vitamin D metabolic genes (CYP27A1, CYP2R1, CYP24A1, GC) and VDRE genes are also associated with asthma.
  • Larger, multi-ethnic studies are needed to confirm findings and guide targeted interventions.
Abstract

Keywords:
Asthma in childrenBiotechnologyGeneticsSingle nucleotide polymorphismsVitamin D associated gene polymorphisms

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