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Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive,
Jeremy J Kudrna1, Tanner J Ferguson2, Russell J Swan3
1Department of Ophthalmology, Penn State College of Medicine, Hershey, PA, USA. jkudrna@pennstatehealth.psu.edu.
Ophthalmology and Therapy
|September 17, 2020
Summary
Negative periocular pressure using the multi-pressure dial (MPD) improved retinal ganglion cell function in ocular hypertensive and glaucoma patients. This pilot study suggests a short-term benefit for steady-state pattern electroretinography (ss-pERG) parameters.
Area of Science:
- Ophthalmology
- Neuroscience
- Medical Devices
Background:
- Evaluates the multi-pressure dial (MPD) effects on steady-state pattern electroretinography (ss-pERG) parameters.
- Pilot trial in ocular hypertensive (OHT), glaucoma suspect, and open-angle glaucoma (OAG) subjects.
- Randomized, controlled, prospective study in a private practice setting.
Purpose of the Study:
- To assess the impact of negative periocular pressure via MPD on ss-pERG.
- To determine if MPD application influences retinal ganglion cell function.
- To investigate short-term functional changes in glaucomatous eyes.
Main Methods:
- Nine patients with OHT, glaucoma suspect, or mild OAG included.
- One eye received negative periocular pressure; the contralateral eye served as control.
- ss-pERG performed using Diopsys High Contrast Sensitivity protocol with MPD.
Main Results:
- Statistically significant improvement in MagnitudeD (MagD) (p=0.023) with negative periocular pressure.
- Trend towards improved MagD/Magnitude ratio (p=0.059) compared to control eyes.
- Negative periocular pressure applied at 50% of baseline intraocular pressure.
Conclusions:
- MPD wear led to short-term improvements in MagD and MagD/Mag ratio.
- Negative periocular pressure on the anterior globe may enhance retinal ganglion cell function.
- Suggests potential for MPD in managing glaucomatous conditions.
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