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Vaccinations in patients with multiple sclerosis: A Delphi consensus statement.

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Vaccinations are crucial for multiple sclerosis (MS) patients to prevent infections. Recommendations guide safe and effective vaccine administration, even for those on disease-modifying therapies, but more research is needed.

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Area of Science:

  • Neurology
  • Immunology
  • Infectious Diseases

Background:

  • Patients with multiple sclerosis (MS) face a higher risk of infections.
  • Vaccinations can reduce infection risks in MS patients, provided they are safe and effective.
  • Consideration must be given to MS patients undergoing disease-modifying drug treatments.

Purpose of the Study:

  • To develop clinical recommendations for vaccination decisions in multiple sclerosis patients.
  • To address the efficacy, safety, and optimal timing of vaccine administration in MS.
  • To provide guidance for healthcare professionals managing MS patient immunizations.

Main Methods:

  • A modified Delphi consensus process was employed from October 2017 to June 2018.
  • Expert panel generated statements and recommendations based on a literature review.
  • Recommendations focused on vaccine efficacy, safety, and timing for MS patients.

Main Results:

  • An 'infectious diseases card' is recommended at diagnosis to manage latent infections.
  • Vaccinations should be implemented at MS diagnosis or timed with MS treatments.
  • Yearly influenza vaccination is advised for all MS patients, irrespective of treatment.

Conclusions:

  • Vaccination in MS patients requires careful risk-benefit assessment.
  • There is a critical need for further research on vaccinations in MS.
  • Evidence-based decision-making for MS patient vaccinations requires more study.