Application of The Dess-Martin Oxidation in Total Synthesis of Natural Products
Majid M Heravi1, Tayebe Momeni1, Vahideh Zadsirjan1
1Department of Chemistry, School of Science, Alzahra University, POBox 1993891176, Vanak, Tehran, Iran.
Abstract:
Dess-Martin periodinane (DMP), a commercially available chemical, is frequently utilized as a mild oxidative agent for the selective oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones, respectively. DMP shows several merits over other common oxidative agents such as chromiumand DMSO-based oxidants; thus, it is habitually employed in the total synthesis of natural products. In this review, we try to underscore the applications of DMP as an effective oxidant in an appropriate step (steps) in the multi-step total synthesis of natural products.
Related Concept Videos
Oxidation of Alcohols
The process of oxidation in a chemical reaction is observed in any of the three forms:
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate
Oxidation and Reduction of Organic Molecules
The removal of an electron from a molecule, results in a...
Radical Autoxidation
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids


