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Updated: Dec 8, 2025

Optical Control of Living Cells Electrical Activity by Conjugated Polymers
Published on: January 28, 2016
Near-infrared light control of membrane potential by an electron donor-acceptor linked molecule
Yuta Takano1, Kazuaki Miyake2, Jeladhara Sobhanan3
1Research Institute for Electronic Science, Hokkaido University, Kita-20, Nishi-10, Sapporo 001-0020, Japan. tak@es.hokudai.ac.jp and Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. imahori@scl.kyoto-u.ac.jp and Graduate School of Environmental Science, Hokkaido University, Kita-10, Nishi-5, Sapporo 060-810, Japan.
Abstract:
Near-infrared (NIR) light control of living cellular activities is a highly desired technique for living cell manipulation because of its advantage of high penetrability towards living tissue. In this study, (π-extended porphyrin)-fullerene linked molecules are designed and synthesized to achieve NIR light control of the membrane potential. A donor-(π-extended porphyrin)-acceptor linked molecule exhibited the formation of the charge-separated state with a relatively long lifetime (0.68 μs) and a moderate quantum yield (27-31%). The hydrophilic trimethylammonium-linked triad molecule successfully altered PC12 cells' membrane potential via photoinduced intramolecular charge separation.
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