Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motor gasoline toxicity.

R A Scala1

  • 1Exxon Biomedical Sciences, Incorporated, East Millstone, New Jersey 08873.

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
|May 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The early days of SOT. Society of Toxicology.

Toxicological sciences : an official journal of the Society of Toxicology·2001
Same author

Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1997
Same author

IRAG working group 6. Guidelines for the evaluation of eye irritation alternative tests: criteria for data submission. Interagency Regulatory Alternatives Group.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·1997
Same author

Subchronic feeding study of four white mineral oils in dogs and rats.

Drug and chemical toxicology·1995
Same author

Major issues in traditional workplace exposure limits.

American Industrial Hygiene Association journal·1992
Same author

An abbreviated repeat dose and reproductive/developmental toxicity test for high production volume chemicals.

Regulatory toxicology and pharmacology : RTP·1992
Same journal

Characterization of the effects of musk ketone on mouse hepatic cytochrome P450 enzymes.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
Same journal

Tetracycline-induced steatosis in primary canine hepatocyte cultures.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
Same journal

Tributyl phosphate effects on urine and bladder epithelium in male Sprague-Dawley rats.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
Same journal

Ketoconazole impairs early pregnancy and the decidual cell response via alterations in ovarian function.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
Same journal

Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
Same journal

Intratracheal inhalation vs intratracheal instillation: differences in particle effects.

Fundamental and applied toxicology : official journal of the Society of Toxicology·1998
See all related articles

Motor gasoline inhalation causes kidney damage primarily in male rats, linked to specific hydrocarbons. The exact mechanism and sex-specific response remain unclear.

Area of Science:

  • Environmental toxicology
  • Occupational health
  • Hydrocarbon chemistry

Background:

  • Motor gasoline is a widely used commodity with complex chemical properties.
  • Previous studies indicate potential health risks associated with gasoline exposure.
  • Understanding gasoline toxicology is crucial for public and occupational safety.

Purpose of the Study:

  • To review the toxicology of motor gasoline.
  • To examine gasoline as a model for studying complex mixtures.
  • To summarize existing inhalation studies and identify knowledge gaps.

Main Methods:

  • Review of previously reported subchronic and chronic inhalation studies.
  • Discussion of experimental design factors: sample verification, species selection, dose selection, and exposure conditions.

Related Experiment Videos

  • Identification of implicated hydrocarbon components.

    • Main Results:

    • Subchronic and chronic inhalation studies primarily showed nephrotoxicity in male rats.
    • Low boiling, highly branched hydrocarbons (C6-C10) are implicated in the observed toxicity.
    • The basis for the male rat-specific response and the precise mechanism of action are not yet understood.

    Conclusions:

    • Motor gasoline poses a toxicological risk, particularly affecting male rat kidneys.
    • Further research is needed to elucidate the sex-specific mechanisms of gasoline toxicity.
    • Refined experimental designs are necessary for accurate toxicological assessment of complex mixtures like gasoline.