Related Experiment Video

Updated: Dec 8, 2025

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

15.3K

Causes and Management of Non-cirrhotic Portal Hypertension​

Stefania Gioia1, Silvia Nardelli2, Lorenzo Ridola2

  • 1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy. stensgioia@hotmail.com.

Current Gastroenterology Reports
|September 17, 2020
PubMed

Insights

Non-cirrhotic portal hypertension (NCPH) encompasses porto-sinusoidal vascular disease (PSVD) and chronic portal vein thrombosis (PVT). Management of these conditions and their complications mirrors that for cirrhosis, with anticoagulation being crucial.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Vascular Medicine

Background:

  • Non-cirrhotic portal hypertension (NCPH) is a complex condition with diverse underlying causes.
  • Porto-sinusoidal vascular disease (PSVD) and chronic portal vein thrombosis (PVT) are primary contributors to NCPH in Western populations.

Purpose of the Study:

  • To provide a comprehensive overview of the nomenclature, diagnostic features, and management strategies for PSVD and chronic PVT.
  • To highlight the importance of recognizing and actively diagnosing these conditions in at-risk patients.

Main Methods:

  • Literature review and synthesis of current knowledge on PSVD and chronic PVT.
  • Analysis of diagnostic criteria and therapeutic approaches for NCPH.

Main Results:

  • Management of NCPH involves treating associated conditions and portal hypertension (PH).
  • PH management in PSVD/PVT parallels that in cirrhosis, with Transjugular Intrahepatic Porto systemic Shunt (TIPS) and liver transplantation as options for severe cases.
  • Anticoagulation is vital for treating thrombosis in PSVD and preventing recurrence in portal cavernoma.

Conclusions:

  • Current management of portal hypertension complications in NCPH aligns with cirrhosis protocols.
  • Further large-scale cooperative studies are needed to elucidate the natural history of NCPH and refine its management strategies.
Abstract

Keywords:
Portal hypertensionPortal vein thrombosisPorto-sinusoidal vascular liver disease

More Related Videos

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

528
Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy07:10

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy

Published on: June 18, 2020

22.1K

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
265
Esophageal Varices-I: Introduction01:24

Esophageal Varices-I: Introduction

Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
841
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
928
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.7K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
514
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
202