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Myocarditis in Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019

Supriya Jain1, Sheila M Nolan2, Aalok R Singh3

  • 1From the Department of Pediatrics, Division of Cardiology.

Cardiology in Review
|September 17, 2020
PubMed

Insights

Children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can develop serious heart problems. Our study details initial experiences managing pediatric acute myocardial injury related to coronavirus disease 2019 (COVID-19).

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Cardiovascular Complications

Background:

  • Cardiac involvement is an emerging complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric populations.
  • Understanding the spectrum of cardiac manifestations in children with coronavirus disease 2019 (COVID-19) is crucial for timely management.

Observation:

  • This report details the initial experience of managing three pediatric patients with acute myocardial injury secondary to COVID-19.
  • The cases illustrate a range of cardiac involvement, including myocarditis, cardiogenic shock, heart failure, biventricular dysfunction, valvulitis, coronary artery abnormalities, and pericardial effusion.

Findings:

  • Children with COVID-19 can present with significant acute myocardial injury.
  • The cardiac manifestations are diverse, mirroring aspects of multisystem inflammatory syndrome in children (MIS-C).

Implications:

  • Early recognition and management of cardiac complications in pediatric COVID-19 are essential.
  • This experience highlights the need for heightened awareness of cardiovascular involvement in children diagnosed with SARS-CoV-2 infection.
  • Further research is warranted to elucidate the long-term cardiovascular sequelae in affected children.

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