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Relation of antifactor Xa activity of heparins and antithrombotic efficacy
1Medical Clinic I, Klinikum Mannheim, University of Heidelberg, FRG.
In the present paper some of the characteristics of the pharmacodynamics of low-molecular-weight (LMW) heparin and the importance of the inhibition of the factor Xa are outlined. In summary, there is some evidence that the inhibition of factor Xa mediated fibrin formation and antithrombotic effects. However, there is a lot of experimental evidence that heparin and LMW heparins induce antithrombotic effects by releasing compounds from vascular endothelium, too. Thus, distinct interactions of heparin and LMW heparins with the cellular compounds of the blood may modulate the antithrombotic and hemorrhagic capacities.
In the present paper some of the characteristics of the pharmacodynamics of low-molecular-weight (LMW) heparin and the importance of the inhibition of the factor Xa are outlined. In summary, there is some evidence that the inhibition of factor Xa mediated fibrin formation and antithrombotic effects. However, there is a lot of experimental evidence that heparin and LMW heparins induce antithrombotic effects by releasing compounds from vascular endothelium, too. Thus, distinct interactions of heparin and LMW heparins with the cellular compounds of the blood may modulate the antithrombotic and hemorrhagic capacities.