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Ribosomal stress-surveillance: three pathways is a magic number
Anna Constance Vind1, Aitana Victoria Genzor1, Simon Bekker-Jensen1
1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
Nucleic Acids Research
|September 17, 2020
Summary
Cells use stress response pathways to maintain balance. This review covers the ribotoxic stress response (RSR), Ribosome-associated Quality Control (RQC), and Integrated Stress Response (ISR), exploring therapeutic targets like ZAKα.
Area of Science:
- Cellular Biology
- Molecular Biology
- Biochemistry
Background:
- Cells activate stress response pathways to maintain homeostasis against environmental insults.
- p38 and JNK MAP kinases are central to stress responses, including the ribotoxic stress response (RSR).
- Ribosomal impairment disrupts protein synthesis, elevates inflammation, and can cause cell death.
Purpose of the Study:
- To provide an overview of three key translation surveillance pathways: RSR, RQC, and ISR.
- To highlight recent advancements in understanding the activation mechanisms of these pathways.
- To discuss the physiological roles and therapeutic potential of RSR.
Main Methods:
- Literature review of stress response pathways.
- Analysis of activation mechanisms for RSR, RQC, and ISR.
- Discussion of commonalities and differences between pathways.
Main Results:
- Overview of RSR, RQC, and ISR pathways.
- Recent advances in understanding pathway activation.
- Comparison of pathway similarities and distinctions.
Conclusions:
- The RSR plays a crucial role in cellular stress response.
- Targeting the ZAKα kinase may offer therapeutic benefits for ribotoxin exposure.
- Further research into these pathways can inform treatment strategies for cellular stress-related conditions.
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