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Phosphorylation01:02

Phosphorylation

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The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
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Preparation of Nitriles01:12

Preparation of Nitriles

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One of the common methods to prepare nitriles is the dehydration of amides. This method requires strong dehydrating agents like phosphorous pentoxide or boiling acetic anhydride for converting amides to nitriles. Another reagent namely, thionyl chloride also accomplishes the dehydration of amides, where amide acts as a nucleophile. The first step of the mechanism involves the nucleophilic attack by the amide on the thionyl chloride to form an intermediate. In the next step, the electron pairs...
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2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

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Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
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Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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Phosphodiester Linkages01:01

Phosphodiester Linkages

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Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
DNA and RNA are polynucleotides or long chains of nucleotides that are linked together. A nucleotide is...
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1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism01:37

1° Amines to Diazonium or Aryldiazonium Salts: Diazotization with NaNO2 Mechanism

4.5K
Nitrous acid is a relatively weak and unstable acid prepared in situ by the reaction of sodium nitrite and cold, dilute hydrochloric acid. In an acidic solution, the nitrous acid undergoes protonation when it loses water to form a nitrosonium ion—an electrophile. Nitrous acid reacts with primary amines to give diazonium salts. The reaction is called diazotization of primary amines.
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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

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Post-Synthetic Modification: Systematic Study on a Simple Access to Nitridophosphates.

Sebastian Wendl1, Lisa Seidl1, Patrick Schüler1

  • 1Department of Chemistry, Ludwig Maximilians University Munich, Butenandtstr. 5-13, 81377, München, Germany.

Angewandte Chemie (International Ed. in English)
|September 17, 2020
PubMed
Summary
This summary is machine-generated.

Researchers explored a new method for synthesizing nitridophosphates by modifying existing compounds with halides. This post-synthetic approach expands the possibilities for creating novel materials with diverse properties.

Keywords:
high-pressure chemistryion exchangenitridesnitridophosphatespost-synthetic modification

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Area of Science:

  • Materials Science
  • Solid-State Chemistry
  • Inorganic Chemistry

Background:

  • Nitridophosphates are a class of nitrides known for properties like luminescence and ion conductivity.
  • Current synthesis methods primarily rely on direct combination of starting materials.

Purpose of the Study:

  • To investigate a post-synthetic modification method for nitridophosphates.
  • To assess the applicability of halide treatment under elevated conditions to various nitridophosphate structures.

Main Methods:

  • Systematic study of post-synthetic modification of pre-synthesized nitridophosphates.
  • Treatment with halides under elevated pressures and temperatures.
  • Investigation of model compounds: BaP2N4, Ba3P5N10Br, SrH4P6N12, CaP8N14, and Ca2PN3.

Main Results:

  • Demonstrated the formation of structurally related and unrelated compounds from starting nitridophosphates.
  • Showcased the versatility of the halide treatment method across different nitridophosphate condensation degrees.
  • Successfully modified framework-, layer-, and chain-type nitridophosphates.

Conclusions:

  • The post-synthetic halide treatment is a promising method for nitridophosphate synthesis.
  • This approach significantly broadens the synthetic accessibility of nitridophosphates.
  • Opens new avenues for discovering nitridophosphate materials with tailored properties.