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Association between pemphigus and psoriasis: a systematic review and meta-analysis
Kevin Phan1, Vignesh Ramachandran, Saxon D Smith
1University of New South Wales, Sydney Department of Dermatology, Liverpool Hospital, Sydney. kphan.vc@gmail.com.
Dermatology Online Journal
|September 17, 2020
Summary
This study found a significant association between pemphigus and psoriasis, indicating pemphigus is more common in psoriasis patients. Further research into shared mechanisms is recommended for improved diagnosis and treatment.
Area of Science:
- Dermatology
- Autoimmune Disorders
- Inflammatory Diseases
Background:
- Pemphigus and psoriasis are distinct autoimmune conditions.
- Case reports suggest a potential link between pemphigus and psoriasis.
- Large-scale investigations into this association are limited.
Discussion:
- This systematic review and meta-analysis evaluated the association between pemphigus and psoriasis.
- Pemphigus was found to be significantly more common in patients with psoriasis compared to controls.
- An odds ratio of 2.64 (95% CI 1.24-5.59, P=0.01) indicates a notable link, despite high heterogeneity (I2=94%).
Key Insights:
- A statistically significant association exists between pemphigus and psoriasis.
- Patients with psoriasis have a higher likelihood of developing pemphigus.
- The findings necessitate exploring shared pathophysiologic pathways.
Outlook:
- Investigating shared pathophysiologic mechanisms is crucial.
- Understanding this association can inform diagnostic strategies.
- This knowledge may guide improved management and treatment approaches for patients with coexisting pemphigus and psoriasis.
