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Risk factors involved in the formation of multiple intracranial aneurysms

Wen-Qiang Xin1, Peng-Ju Sun2, Fan Li2

  • 1Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, 300052, PR China; Department of Neurology, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075, Goettingen, Germany.

Clinical Neurology and Neurosurgery
|September 17, 2020
PubMed
Abstract

Insights

Female sex, older age, cigarette smoking, and a family history of hypertension are key risk factors for developing multiple intracranial aneurysms (MIAs). Awareness of these factors is crucial for prevention and early detection of MIAs.

Area of Science:

  • Neurology
  • Vascular Surgery
  • Epidemiology

Background:

  • Multiple intracranial aneurysms (MIAs) pose a significant clinical challenge.
  • Existing research on MIAs risk factors is often controversial.
  • A comprehensive analysis is needed to clarify these associations.

Purpose of the Study:

  • To identify independent risk factors for the formation of multiple intracranial aneurysms (MIAs).
  • To combine clinical data analysis with meta-analysis for robust findings.

Main Methods:

  • Retrospective review of medical records for patients with aneurysms.
  • Univariate and binary logistic regression analyses were performed on clinic data.
  • Meta-analysis was conducted to synthesize findings from existing literature.

Main Results:

  • The study included 565 patients; 116 had MIAs and 449 had single intracranial aneurysms (SIAs).
  • Independent risk factors for MIAs identified: female sex (OR=1.624), primary hypertension (OR=1.563), and family history of hypertension (OR=2.496).
  • Meta-analysis confirmed significant associations of MIAs with female sex, cigarette smoking, primary hypertension, and older age.

Conclusions:

  • Older age and female sex are strongly associated with a higher incidence of MIAs.
  • Hypertension history, cigarette smoking, and family history of hypertension are significant contributing factors.
  • These identified risk factors warrant attention for preventative strategies and clinical vigilance.
Keywords:
Intracranial aneurysmsMeta-analysisMultiple intracranial aneurysmsRisk factorsSingle intracranial aneurysms

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