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Updated: Dec 8, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
Calcium signaling and epigenetics: A key point to understand carcinogenesis
Eduardo Izquierdo-Torres1, Andrés Hernández-Oliveras2, Gabriela Fuentes-García1
1Departamento De Bioquímica, Facultad De Medicina. Universidad Nacional Autónoma De México, Ciudad De México, Mexico.
Abstract:
Calcium (Ca2+) signaling controls a wide range of cellular processes, including the hallmarks of cancer. The Ca2+ signaling system encompasses several types of proteins, such as receptors, channels, pumps, exchangers, buffers, and sensors, of which several are mutated or with altered expression in cancer cells. Since epigenetic mechanisms are disrupted in all stages of carcinogenesis, and reversibly regulate gene expression, they have been studied by different research groups to understand their role in Ca2+ signaling remodeling in cancer cells and the carcinogenic process. In this review, we link Ca2+ signaling, cancer, and epigenetics fields to generate a comprehensive landscape of this complex group of diseases.
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