CT texture analysis compared to Positron Emission Tomography (PET) and mutational status in resected melanoma...

To evaluate the potential of CT texture analysis parameters and metabolic characteristics of melanoma metastases in ¹⁸F- FDG PET/CT to predict relevant mutations of tumour cells for targeted therapy in metastatic melanoma patients in correlation with histopathologic specimen.

66 melanoma patients, examined with contrast-enhanced ¹⁸F-FDG PET/CT before scheduled metastasectomy without any prior systemic therapy, were included in this single-centre retrospective analysis under IRB waiver. The largest, resected metastasis in each patient was assessed with CT texture analysis and semiquantitative ¹⁸F-FDG PET parameters. Correlation between imaging parameters and histopathological mutations (BRAF- and NRAS- genes) were calculated.

Attenuation standard deviation (SD) within target lesion indicated a weak correlation with its SUV_peak (rho -0.292, p 0.017). However, no correlation between CT texture analysis, metabolic ¹⁸F-FDG PET parameters and tumour cell mutation could be established.

CT texture parameters cannot replace the diagnostic value of ¹⁸F- FDG PET/CT for metabolic information in melanoma patients. Discrimination between BRAF- and NRAS mutation status was not feasible with CT texture analysis in this exploratory study.