Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

9.1K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.1K
COP Coated Vesicles00:59

COP Coated Vesicles

16.0K
Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
16.0K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

4.4K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
4.4K
Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

16.3K
Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...
16.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applications of enhanced sampling methods to biomolecular self-assembly: a review.

Journal of physics. Condensed matter : an Institute of Physics journal·2025
Same author

Martini 3 coarse-grained model of enzymes: Framework with validation by all-atom simulations and x-ray diffraction measurements.

The Journal of chemical physics·2025
Same author

Potential Microfluidic Devices for COVID-19 Antibody Detection at Point-of-Care (POC): A Review.

IEEE sensors journal·2023
Same author

Multiscale, Multiresolution Coarse-Grained Model via a Hybrid Approach: Solvation, Structure, and Self-Assembly of Aromatic Tripeptides.

Journal of chemical theory and computation·2023
Same author

A coarse-grained Molecular Dynamics study of phase behavior in Co-assembled lipomimetic oligopeptides.

Journal of molecular graphics & modelling·2023
Same author

A hybrid approach for coarse-graining helical peptoids: Solvation, secondary structure, and assembly.

The Journal of chemical physics·2023

Related Experiment Video

Updated: Dec 8, 2025

In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth
07:10

In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth

Published on: June 28, 2019

6.0K

Peptide-based vesicles and droplets: a review.

Srinivas Mushnoori1, Chien Y Lu1, Kassandra Schmidt2

  • 1Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, United States of America.

Journal of Physics. Condensed Matter : an Institute of Physics Journal
|September 17, 2020
PubMed
Summary

Peptide assembly enables the creation of nanostructures for drug delivery. Researchers are reviewing peptide-based vesicles and nanospheres, exploring aromatic and aliphatic amino acids for controlled payload delivery.

Keywords:
dropletnanospherepeptidevesicle

More Related Videos

Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles
08:53

Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles

Published on: September 19, 2025

910
Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
08:35

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

15.3K

Related Experiment Videos

Last Updated: Dec 8, 2025

In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth
07:10

In Vesiculo Synthesis of Peptide Membrane Precursors for Autonomous Vesicle Growth

Published on: June 28, 2019

6.0K
Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles
08:53

Using the Droplet Transfer Method to Reliably Prepare Giant Unilamellar Vesicles

Published on: September 19, 2025

910
Lipid Bilayer Vesicle Generation Using Microfluidic Jetting
08:35

Lipid Bilayer Vesicle Generation Using Microfluidic Jetting

Published on: February 21, 2014

15.3K

Area of Science:

  • Biomolecular Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Peptide assembly offers a versatile platform for designing biomolecular structures.
  • Engineered peptides can form diverse supramolecular assemblies like vesicles and nanorods.
  • Spherical peptide nanostructures are particularly valuable for encapsulation and controlled release.

Purpose of the Study:

  • To summarize the current state of peptide-based vesicles and nanospheres.
  • To provide an overview of peptide assembly into nanovesicles and nanospheres.
  • To discuss the role of different amino acid side chains in these assemblies.

Main Methods:

  • Review of experimental and computational approaches for peptide assembly.
  • Analysis of aromatic amino acid residues, focusing on phenylalanine and tyrosine.
  • Examination of aliphatic amino acid residues, including alanine, valine, lysine, glycine, proline, and aspartic acid.

Main Results:

  • Peptide self-assembly allows for precise engineering of nanostructures with tunable properties.
  • Aromatic amino acids, particularly phenylalanine, are key in forming specific nanostructures.
  • Aliphatic amino acids offer broader possibilities for creating diverse vesicle and droplet morphologies.
  • Both experimental and computational methods are crucial for understanding and designing peptide assemblies.

Conclusions:

  • Peptide-based nanostructures, especially vesicles and nanospheres, hold significant promise for nanomedicine and targeted drug delivery.
  • The choice of amino acid side chains (aromatic vs. aliphatic) dictates the morphology and properties of the assembled nanostructures.
  • Further research into peptide assembly mechanisms and applications is warranted to fully exploit their potential.