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A decrease in the tear secretion volume in a mouse model with ulcerative colitis.

Hidehisa Sekijima1,2, Keiichi Hiramoto2, Shuji Kozawa1

  • 1Department of Forensic Medicine and Sciences, Graduate School of Medicine, Mie University, Tsu, Mie, Japan.

Cutaneous and Ocular Toxicology
|September 18, 2020
PubMed
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Ulcerative colitis (UC) in mice models causes dry eye by reducing tear volume and damaging lacrimal glands. This inflammation is linked to increased inflammatory markers and decreased aquaporin-5 expression.

Area of Science:

  • Ophthalmology
  • Gastroenterology
  • Immunology

Background:

  • Dry eye syndrome is a common complication of systemic inflammatory diseases.
  • The link between ulcerative colitis (UC) and dry eye, particularly the underlying mechanisms, requires further investigation.

Purpose of the Study:

  • To investigate tear secretion volume in a mouse model of UC.
  • To determine the differences in tear secretion between control and dextran sodium sulphate (DSS)-treated mice.

Main Methods:

  • UC was induced in mice using oral administration of 5.0% DSS for 7 days.
  • Tear volume was measured via Schirmer's test; colon and ocular tissues were analyzed histologically and for protein expression.
  • Plasma levels of TNF-α and IL-6 were quantified, and TUNEL staining assessed apoptosis in lacrimal glands.
Keywords:
Apoptosisaquaporin-5dry eyelacrimal glandulcerative colitis

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Main Results:

  • DSS-treated mice exhibited reduced tear volume compared to controls.
  • Elevated plasma levels of TNF-α and IL-6 were observed in DSS-treated mice.
  • Inflammatory cell infiltration, increased apoptosis (TUNEL-positive cells), and decreased aquaporin-5 expression were noted in the lacrimal glands of DSS-treated mice.

Conclusions:

  • Reduced tear volume in UC is associated with functional impairment of the inflamed lacrimal gland.
  • These findings offer insights into the pathogenesis of dry eye in UC patients.
  • The results may inform the development of therapeutic strategies for dry eye associated with UC.