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Updated: Dec 8, 2025
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Lupus hepatitis, more than just elevated liver enzymes
W Afzal1, M Haghi2, S A Hasni3
1Sanford School of Medicine, University of South Dakota , Sioux Falls, SD, USA.
Scandinavian Journal of Rheumatology
|September 18, 2020
Summary
Systemic lupus erythematosus (SLE) can affect the liver, though it is rare and usually mild. This review covers lupus hepatitis, focusing on its causes, diagnosis, and management.
Area of Science:
- Rheumatology
- Hepatology
- Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect any organ, including the liver.
- Liver involvement in SLE is uncommon, not a diagnostic criterion, and typically presents with mild enzyme elevations.
- Advanced liver disease like cirrhosis is extremely rare in SLE patients.
Purpose of the Study:
- To review the pathogenesis, diagnosis, differential diagnosis, clinical manifestations, management, complications, and prognosis of lupus hepatitis.
- To elucidate the role of liver involvement in SLE.
- To provide a comprehensive overview of lupus hepatitis.
Main Methods:
- Literature review of studies on SLE and liver involvement.
- Analysis of clinical manifestations, diagnostic criteria, and treatment outcomes.
- Discussion of differential diagnoses and potential complications.
Main Results:
- Liver disease in SLE is usually mild, with elevated liver enzymes being the most common sign.
- Hepatocellular, cholestatic, or vascular changes can occur, but specific pathology is often unclear.
- Other causes of liver dysfunction must be excluded; corticosteroids may be used but carry risks like non-alcoholic fatty liver disease.
Conclusions:
- Liver involvement is not a primary driver of morbidity or mortality in SLE.
- Accurate diagnosis requires excluding other liver disease causes.
- Management involves corticosteroids, with careful monitoring for side effects and complications.
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