Related Experiment Video
Updated: Dec 8, 2025
08:45
LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring
Published on: November 17, 2018
13.9K
Orbital involvement of Sitosterolemia
Linda O Okafor1, Jeremy Bowyer1, Caroline Thaung2
1Department of Ophthalmology, Royal Stoke University Hospital, Stoke-on-Trent, UK.
Orbit (Amsterdam, Netherlands)
|September 18, 2020
Summary
Sitosterolemia, a rare inherited disorder, can manifest as periocular xanthomas. Early diagnosis is crucial to prevent misdiagnosis as hypercholesterolemia and manage associated cardiovascular risks.
Area of Science:
- Genetics and Metabolism
- Dermatology and Ophthalmology
Background:
- Sitosterolemia is a rare inherited disorder of impaired plant sterol excretion.
- Characterized by xanthomas and premature atherosclerosis.
Observation:
- First reported case of sitosterolemia manifesting in the periorbital region.
- A 44-year-old man presented with a six-month history of a left eyebrow soft tissue mass.
Findings:
- MRI revealed an orbital soft tissue mass.
- Biopsy confirmed a xanthogranulomatous process consistent with sitosterolemia.
Implications:
- Highlights a rare condition with potential periocular manifestation.
- Emphasizes the importance of differentiating from hypercholesterolemia to ensure appropriate management and prevent cardiovascular complications.
Related Concept Videos
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.2K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.2K
01:29Cholesterol: Significance and Regulation
1.1K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.1K
01:24Lipid Absorption
2.1K
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
2.1K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
475
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
475
01:25Lipid Catabolism
619
Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...
619
01:06Lipid Digestion
97.8K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
97.8K