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Current Therapeutic Options for the Treatment of Juvenile Idiopathic Arthritis

Ioanna G Saougou1, Theodora E Markatseli1, Paraskevi V Voulgari1

  • 1Department of Internal Medicine, Rheumatology Clinic, Medical School, University of Ioannina, Ioannina, Greece.

Current Rheumatology Reviews
|September 18, 2020
PubMed

Insights

Juvenile idiopathic arthritis (JIA) treatment has evolved from traditional drugs to advanced biologic therapies. These innovations offer better functional outcomes and joint preservation for children with JIA.

Area of Science:

  • Rheumatology
  • Pediatric Immunology

Background:

  • Juvenile idiopathic arthritis (JIA) is a chronic inflammatory condition affecting children under 16.
  • Current JIA management relies on a combination of pharmacologic and non-pharmacologic interventions.
  • While not curable, JIA treatment has seen significant advancements.

Purpose of the Study:

  • To review the evolution of JIA therapeutic strategies.
  • To highlight the impact of recent advancements, particularly biologic therapies, on JIA management.
  • To discuss current guidelines for optimal JIA care.

Main Methods:

  • Literature review of relevant scientific publications.
  • Analysis of historical and contemporary JIA treatment modalities.
  • Discussion of international clinical practice guidelines.

Main Results:

  • Biologic therapies have significantly improved functional activity and reduced joint damage in JIA patients.
  • Conventional treatments like NSAIDs, DMARDs, and corticosteroids have been supplemented by targeted biologic agents.
  • Recent guidelines provide a framework for evidence-based JIA management.

Conclusions:

  • Biologic therapies represent a major advancement in JIA treatment, improving patient outcomes.
  • The integration of new therapies and updated guidelines has transformed JIA care.
  • Continued research and adherence to guidelines are crucial for optimizing long-term JIA management.

Keywords:
ACR recommendationJIAbDMARDsclassification criteriacsDMARDstreatment

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