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Cellular heterogeneity in human epithelial neoplasms.

W J Mackillop1, G Dotsikas

  • 1Department of Oncology, Queen's University, Kingston, Ontario, Canada.

International Journal of Cell Cloning
|May 1, 1988
PubMed
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This review clarifies knowns and unknowns of tumor cell heterogeneity in human cancers. It distinguishes direct observations from inferences, focusing on human cancer evidence for pathogenesis models.

Area of Science:

  • Oncology
  • Cell Biology

Background:

  • Tumor cell heterogeneity is a widely reviewed topic.
  • Existing reviews may not differentiate direct tumor observations from analogous system inferences.

Purpose of the Study:

  • To detail current knowledge of cellular heterogeneity in human tumors.
  • To critically evaluate pathogenesis models using human cancer evidence.

Main Methods:

  • Review of existing literature on tumor cell heterogeneity.
  • Analysis of evidence from human cancer studies.
  • Comparison of direct observations versus inferred data.

Main Results:

  • Identification of established knowledge regarding human tumor heterogeneity.
  • Assessment of the validity of current heterogeneity pathogenesis models.

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  • Distinction between empirical data and theoretical constructs.

    • Conclusions:

    • A clearer understanding of human tumor cell heterogeneity is presented.
    • Current models of pathogenesis are discussed in the context of available human cancer evidence.