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Updated: Dec 8, 2025
Isolation of Human Islets from Partially Pancreatectomized Patients
Published on: July 30, 2011
Pancreatic insufficiency following pancreatectomy: Does underlying tumor syndrome confer a greater risk?
James D McDonald1, Shreya Gupta1, Mackenzie L Shindorf1
1Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Background:
The risk of postoperative pancreatic exocrine insufficiency (PPEI) is unknown in patients with multiple endocrine neoplasia type I (MEN1) and von Hippel-Lindau (VHL) who require resection of pancreatic neuroendocrine tumors (PNETs).
Methods:
A retrospective review of patients who underwent resection of PNETs at the National Institutes of Health from 2007 to 2019 was performed.
Results:
Our cohort included 82 patients (VHL n = 25, MEN1 n = 20, sporadic n = 37), 6 of whom developed PPEI. While VHL compared to all non-VHL patients (p = 0.046), non-functional PNETs (p = 0.050), and pancreaticoduodenectomy (PD) (p=<0.001) were associated with higher rates of PPEI on univariate analysis, only PD was found to be an independent predictor of PPEI on multivariate analysis (OR 14.43, 95% CI 1.43-145.8, p = 0.024).
Conclusions:
The rate of PPEI in patients with hereditary tumor syndromes was similar to that of sporadic PNETs. PD was independently associated with PPEI, and this increased risk should be included in preoperative counseling.
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