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Anticoagulant Therapy for Patients with Coronavirus Disease 2019: Urgent Need for Enhanced Awareness

Maki Komiyama1, Koji Hasegawa1

  • 1Division of Translational Research, National Hospital Organization Kyoto Medical Center Kyoto, Japan.

European Cardiology
|September 18, 2020
PubMed

Insights

Anticoagulant therapy may improve outcomes for patients with COVID-19, a serious respiratory illness. Further research is needed to confirm the safety and effectiveness of these treatments for coronavirus disease 2019.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is a global pandemic.
  • SARS-CoV-2 infection damages vascular endothelial cells via the ACE2 receptor.
  • Thrombotic cardiovascular complications are a significant COVID-19 symptom, alongside respiratory failure.

Purpose of the Study:

  • To review the current evidence on anticoagulant therapy for COVID-19.
  • To highlight the need for further validation of anticoagulant therapy's safety and effectiveness.
  • To increase awareness of anticoagulant therapy as a potential treatment for COVID-19.

Main Methods:

  • Review of multiple retrospective studies on anticoagulant therapy in COVID-19 patients.
  • Analysis of the suggested benefits of anticoagulation on prognosis.
  • Identification of the need for prospective validation studies.

Main Results:

  • Retrospective studies suggest a positive impact of anticoagulant therapy on COVID-19 prognosis.
  • Anticoagulant therapy is associated with improved outcomes in some patient cohorts.
  • The precise safety and efficacy profile requires further investigation.

Conclusions:

  • Anticoagulant therapy shows promise for improving COVID-19 outcomes.
  • Further clinical trials are essential to validate these findings.
  • Increased clinical awareness and research are crucial for optimizing COVID-19 treatment strategies.
Keywords:
COVID-19SARS-CoV-2anticoagulantthrombosis

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