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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Sensorimotor function in progressive multiple sclerosis.

Jules D Miehm1, John Buonaccorsi2, Jongil Lim3

  • 1Department of Kinesiology, University of Massachusetts Amherst, USA.

Multiple Sclerosis Journal - Experimental, Translational and Clinical
|September 18, 2020
PubMed
Summary
This summary is machine-generated.

Subtle sensorimotor changes in multiple sclerosis (MS) can be detected using non-ambulatory tests. These tests reveal differences between relapsing-remitting and progressive MS, highlighting the importance of assessing both upper and lower limb function.

Keywords:
Relapsing–remitting multiple sclerosiscutaneous sensationprogressive multiple sclerosisproprioceptiontapping performance

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Area of Science:

  • Neurology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • A sensitive test for subtle sensorimotor changes in progressive multiple sclerosis (MS), independent of mobility, is lacking.
  • Current assessments may not fully capture disease progression in non-ambulatory MS patients.

Purpose of the Study:

  • To investigate non-ambulatory upper and lower extremity sensorimotor function.
  • To identify potential differences between relapsing-remitting MS (RRMS) and progressive MS (PMS).

Main Methods:

  • Assessed cutaneous sensitivity, proprioception, and central motor function in 32 RRMS, 31 PMS patients, and 30 controls.
  • Utilized non-ambulatory measures, including foot-tap and hand-tap speed.
  • Compared sensorimotor function with mobility assessed by the 25-foot walk test.

Main Results:

  • Cutaneous sensation differed between RRMS and PMS at the foot and hand.
  • Proprioception differed between RRMS and PMS in the upper extremity, and in both extremities between MS patients and controls.
  • Lower extremity central motor function (foot-tap speed) was impaired in PMS compared to RRMS.
  • Non-ambulatory measures were more sensitive than the 25-foot walk test in differentiating RRMS from PMS.

Conclusions:

  • Novel insights into sensorimotor function changes in PMS versus RRMS.
  • Emphasizes the importance of assessing both upper and lower extremity sensorimotor function.
  • Proprioceptive function loss is evident in MS, with greater loss in PMS compared to RRMS.