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CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value

Jie Wu1, Lan Li1, Siyi Wu1

  • 1Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Cancer Biology & Medicine
|September 18, 2020
PubMed

Insights

The CMTM family of proteins (CMTM1-8) are implicated in cancer development and progression. Understanding their roles in tumor growth, metastasis, and immune evasion could lead to new cancer therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The CKLF-like MARVEL transmembrane domain containing (CMTM) gene family, including CMTM1-8, is frequently dysregulated in human cancers.
  • CMTM proteins possess a conserved MARVEL domain crucial for vesicle trafficking and membrane linking.

Purpose of the Study:

  • To review recent findings on the roles of CMTM1-8 in cancer development.
  • To discuss the potential of CMTMs as therapeutic targets and biomarkers in oncology.

Main Methods:

  • Literature review of in vivo and in vitro studies on CMTM proteins in cancer.
  • Analysis of CMTM gene expression and functional data in various cancer types.

Main Results:

  • CMTM proteins influence critical cancer processes: growth factor receptor signaling, proliferation, apoptosis, metastasis, and immune evasion.
  • Emerging evidence suggests complex and multifactorial mechanisms of action for CMTM proteins.

Conclusions:

  • Dysregulation of CMTM family members is a common hallmark of human cancers.
  • CMTM proteins play significant roles in tumor growth, metastasis, and immune evasion.
  • CMTMs represent promising novel drug targets and biomarkers for cancer treatment and diagnosis.
Keywords:
CMTM familyEGFREMTapoptosiscancercell cycletumor immunity

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