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Dexmedetomidine as an Additive to Local Anesthesia for Decreasing Intraocular Pressure in Glaucoma Surgery: A
Hassan Ali1, Sherif Eissa2, Heba Magdy2
1Anesthesia Department, Cairo University, Cairo, Egypt.
Anesthesiology and Pain Medicine
|September 18, 2020
Summary
Dexmedetomidine did not lower intraocular pressure (IOP) in glaucoma patients receiving a peribulbar block. This study found no significant IOP reduction with dexmedetomidine as an adjuvant medication.
Area of Science:
- Ophthalmology
- Anesthesiology
- Pharmacology
Background:
- Peribulbar block is a common technique in glaucoma surgery.
- A known side effect of peribulbar block is increased intraocular pressure (IOP).
- Dexmedetomidine has shown IOP-lowering effects in non-glaucomatous eyes.
Purpose of the Study:
- To evaluate the efficacy of dexmedetomidine as an adjuvant to peribulbar block in reducing IOP in glaucomatous eyes.
- To assess the impact of different dexmedetomidine dosages (25 µg and 50 µg) on IOP.
- To compare IOP changes in patients receiving dexmedetomidine versus a control group.
Main Methods:
- A triple-blinded randomized study involving 98 eyes.
- Participants were divided into three groups: D50 (dexmedetomidine 50 µg), D25 (dexmedetomidine 25 µg), and a control group (plain peribulbar block).
- IOP was measured before and after block injection, and after surgery.
Main Results:
- Pre-injection IOP and IOP immediately after block injection showed no statistically significant differences between the groups (P > 0.05).
- Post-surgery IOP measurements were similar across all three groups (D50, D25, and C), with no statistically significant differences (P > 0.05).
- The study did not observe a decrease in IOP attributable to dexmedetomidine in glaucomatous eyes.
Conclusions:
- Dexmedetomidine, when used as an adjuvant to peribulbar block, did not effectively decrease intraocular pressure in glaucomatous eyes.
- The findings suggest that dexmedetomidine may not be a suitable adjuvant for managing IOP in this specific surgical context.
- Further research may be needed to explore alternative adjuvant medications or strategies for IOP control during glaucoma surgery.
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