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Updated: Dec 8, 2025

Tractable In Vivo Reprogramming of Tumor Cells to Type 1 Conventional Dendritic Cell-like Cells
Published on: August 1, 2025
Overcoming resistance to immunotherapy by teaching old drugs new tricks
John M Perry1,2,3, Linheng Li2,4
1Children's Mercy Kansas City, Kansas City, MO, USA.
Abstract:
Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from their normal counterparts. However, low doses of doxorubicin can target CSCs by restoring anticancer immunity.
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