PHOSPHOINOSITIDES AND CALCIUM SIGNALING. A MARRIAGE ARRANGED IN ER-PM CONTACT SITES

Calcium (Ca²⁺) ions are critically important in orchestrating countless regulatory processes in eukaryotic cells. Consequently, cells tightly control cytoplasmic Ca²⁺ concentrations using a complex array of Ca²⁺-selective ion channels, transporters, and signaling effectors. Ca²⁺ transport through various cellular membranes is highly dependent on the intrinsic properties of specific membrane compartments and conversely, local Ca²⁺ changes have profound effects on the membrane lipid composition of such membrane sub-domains. In particular, inositol phospholipids are a minor class of phospholipids that play pivotal roles in the control of Ca²⁺-dependent signaling pathways. In this review, we will highlight some of the recent advances in this field as well as their impact in defining future research directions.