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An Improved Protocol to Purify and Directly Mono-Biotinylate Recombinant BDNF in a Tube for Cellular Trafficking Studies in Neurons
Published on: July 11, 2020
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The physiology of regulated BDNF release
Tanja Brigadski1, Volkmar Leßmann2,3
1Department of Informatics and Microsystem Technology, University of Applied Sciences Kaiserslautern, D-66482, Zweibrücken, Germany. tanja.brigadski@hs-kl.de.
Cell and Tissue Research
|September 18, 2020
Summary
Brain-Derived Neurotrophic Factor (BDNF) is crucial for brain health and function. This review details stimuli affecting BDNF release, vital for understanding neurological and cardiovascular diseases.
Area of Science:
- Neuroscience
- Molecular Biology
- Cell Biology
Background:
- Brain-Derived Neurotrophic Factor (BDNF) is a key regulator of neural development, plasticity, regeneration, and protection.
- Altered BDNF levels in blood and tissue are linked to neurodegenerative, neurological, and cardiovascular diseases.
- Understanding stimuli affecting BDNF concentration is crucial for disease relevance.
Purpose of the Study:
- To review stimuli that induce BDNF release.
- To summarize molecular mechanisms regulating BDNF release efficacy.
- To focus on BDNF release from brain-originating cells.
Main Methods:
- Literature review of studies on BDNF expression and release.
- Focus on neuronal preparations and brain-derived cells.
- Analysis of physiological and pathophysiological stimuli.
Main Results:
- Summarizes various stimuli that trigger BDNF release.
- Highlights molecular mechanisms governing BDNF release efficiency.
- Discusses regulated BDNF release under physiological conditions.
Conclusions:
- Detailed knowledge of BDNF regulation is essential for understanding its role in health and disease.
- This review consolidates current understanding of BDNF release mechanisms.
- Further research into BDNF stimuli can inform therapeutic strategies for neurological disorders.
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