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Updated: Aug 9, 2026

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
Published on: September 20, 2011
Dual-responsive mesoporous silica nanoparticles coated with carbon dots and polymers for drug encapsulation and
Xiaona Li1, Shun Hu1, Zhe Lin1
1Liaoning Province Key Laboratory for Green Synthesis & Preparative Chemistry of Advanced Materials, College of Chemistry, Liaoning University, Shenyang, 110036, PR China.
Abstract:
Aim: Smart mesoporous silica nanoparticles (MSNs) coated with carbon dots (CDs) and poly(N-vinylcaprolactam) (PNVCL) as a mixed shell (CDs/PNVCL polymer grafted MSNs) were prepared for pH-trigged anticancer drug release and real-time monitoring. Materials & methods: The amino-terminated PNVCL and amino-rich CDs were grafted onto the surface of aldehyde group functionalized MSNs through Schiff base reaction. Doxorubicin (DOX) was loaded into the prepared nanoparticles. Results: DOX could be quickly released in the tumor environment, leading to cell apoptosis. The linear fit between the percentage of released DOX and the fluorescence intensity of CDs indicated that the change in fluorescence intensity could be used to monitor drug release in real time. Conclusion: The as-prepared CDs/PNVCL polymer grafted MSNs are promising candidates for integrating controllable release and real-time monitoring in cancer treatment.
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