Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

3.3K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.3K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

4.4K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In silico repurposing of clinically approved drugs as potential BRAF inhibitors: a pharmacophore-based virtual screening and experimental investigation.

Cancer cell international·2026
Same author

Novel benzothiazole-indole acetamides as potential anticancer agents: synthesis, biological evaluation, and <i>in silico</i> studies.

RSC advances·2026
Same author

Finding and computational analyses of a novel mutation in CEP78 linked to cone-rod dystrophy and hearing loss.

Human molecular genetics·2026
Same author

Metformin as a promising therapeutic option for reducing substance withdrawal syndromes: A narrative review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Stem cell-directed targeted chemotherapy primes drug-resistant metastatic ovarian tumors for elimination by natural killer cells.

Molecular therapy. Oncology·2026
Same author

A systematic review on the potential of modulating the IRE arm of the UPR in U87 and U251 glioblastoma cells for improved therapeutic efficacy.

Molecular biology research communications·2026

Related Experiment Video

Updated: Dec 8, 2025

Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

717

Small extracellular vesicles (sEVs): discovery, functions, applications, detection methods and various engineered

Manica Negahdaripour1,2, Hajar Owji2, Sedigheh Eskandari2

  • 1Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Expert Opinion on Biological Therapy
|September 18, 2020
PubMed
Summary

Extracellular vesicles (EVs), particularly small EVs (sEVs), are vital cell communicators involved in numerous biological processes and diseases. Research highlights their therapeutic and diagnostic potential.

Keywords:
Extracellular vesiclesdetection methodsdiagnosticdrug deliveryfunctionssevs

More Related Videos

Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry
12:27

Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry

Published on: July 26, 2022

5.4K
Extraction of Extracellular Vesicles from Whole Tissue
09:03

Extraction of Extracellular Vesicles from Whole Tissue

Published on: February 7, 2019

15.8K

Related Experiment Videos

Last Updated: Dec 8, 2025

Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

717
Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry
12:27

Single Extracellular Vesicle Transmembrane Protein Characterization by Nano-Flow Cytometry

Published on: July 26, 2022

5.4K
Extraction of Extracellular Vesicles from Whole Tissue
09:03

Extraction of Extracellular Vesicles from Whole Tissue

Published on: February 7, 2019

15.8K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Background:

  • Extracellular vesicles (EVs) are crucial for intercellular communication, transporting proteins, lipids, and nucleic acids.
  • Small EVs (sEVs), once thought to be waste, are now recognized for diverse biological and pathological roles.

Purpose of the Study:

  • To review the multifaceted roles of EVs, with a focus on sEVs.
  • To elaborate on the structural, molecular, and functional aspects of sEVs.

Main Methods:

  • Literature review of current research on EVs and sEVs.
  • Analysis of EV classification based on size, density, morphology, content, and biogenesis.

Main Results:

  • EVs are implicated in immunoregulation, CNS development, tissue regeneration, inflammation, and disease pathogenesis.
  • sEVs play critical roles in cancer, neurodegenerative diseases, infections, and metabolic disorders.

Conclusions:

  • sEVs are key players in various physiological and pathological processes.
  • Understanding sEVs opens avenues for therapeutic, diagnostic, and drug delivery applications.