Related Experiment Video

Updated: Dec 8, 2025

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
04:53

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

11.0K

Clinical Trial Subinvestigator: An Emerging Role for Oncology Nurse Practitioners

Clover Patterson1, Fedricker D Barber1

  • 1University of Texas MD Anderson Cancer Center.

Clinical Journal of Oncology Nursing
|September 18, 2020
PubMed

Insights

Oncology nurse practitioners (ONPs) are crucial in phase 1 cancer trials. They manage adverse events and ensure protocol adherence, improving patient care and trial integrity.

Area of Science:

  • Oncology Nursing
  • Clinical Trial Management
  • Advanced Practice Nursing

Background:

  • Phase 1 clinical trials are vital for advancing cancer care.
  • Investigational agents can cause adverse events, impacting patient well-being and performance.
  • Advanced practice nurses are increasingly involved in clinical research.

Purpose of the Study:

  • To highlight the expanding role of oncology nurse practitioners (ONPs) as subinvestigators in phase 1 cancer trials.
  • To emphasize the importance of ONPs in managing treatment-related toxicities.
  • To underscore the ONP's contribution to maintaining clinical trial integrity.

Main Methods:

  • This is a conceptual/practice-based abstract, not reporting empirical results.
  • Focuses on the described responsibilities and contributions of ONPs in phase 1 trials.
  • Literature review and expert opinion synthesis regarding the ONP role.

Main Results:

  • ONPs provide expert oncology care within the unique setting of phase 1 trials.
  • ONPs are integral to the early recognition and management of adverse events.
  • ONPs play a key role in ensuring participant safety and adherence to trial protocols.

Conclusions:

  • The role of ONPs as subinvestigators is essential for successful phase 1 cancer trials.
  • ONPs enhance patient safety and optimize the management of toxicities.
  • Integrating ONPs strengthens the infrastructure for cancer clinical research.
Keywords:
nurse practitionersphase 1 oncology clinical trialsubinvestigator

More Related Videos

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.7K
A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines07:59

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

9.3K

Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.4K
Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.0K
Nursing Ethical Principles II01:27

Nursing Ethical Principles II

Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
1.7K
Interdisciplinary Care: The Health Care Team-I01:21

Interdisciplinary Care: The Health Care Team-I

An interdisciplinary team includes many healthcare professionals working together and utilizing their skills, knowledge, and expertise to provide holistic and quality patient care.
Physicians
The physician's primary responsibility is to diagnose illness and direct the medical or surgical treatment of the condition. The authority to admit patients to a healthcare agency or institution and practice care within that setting is granted to physicians by the healthcare agency or institution...
2.4K
Nurses' Legal Responsibilities I01:27

Nurses' Legal Responsibilities I

In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:
1.2K
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.6K