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Updated: Dec 8, 2025

A Novel In Vitro Wound Healing Assay to Evaluate Cell Migration
Published on: March 17, 2018
First Structure-Activity Relationship Study of Potent BLT2 Agonists as Potential Wound-Healing Promoters
Victor Hernandez-Olmos1, Jan Heering1, Viktoria Planz2
1Branch for Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany.
Abstract:
The first potent leukotriene B4 (LTB4) receptor type 2 (BLT2) agonists, endogenous 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT), and synthetic CAY10583 (CAY) have been recently described to accelerate wound healing by enhanced keratinocyte migration and indirect stimulation of fibroblast activity in diabetic rats. CAY represents a very valuable starting point for the development of novel wound-healing promoters. In this work, the first structure-activity relationship study for CAY scaffold-based BLT2 agonists is presented. The newly prepared derivatives showed promising in vitro wound-healing activity.
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