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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

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Ultrahigh Resolution Mouse Optical Coherence Tomography to Aid Intraocular Injection in Retinal Gene Therapy Research
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Creating a Health Utility Value for Birdshot Chorioretinopathy.

Anisha Sekaran1,2, Mohith Shamdas1,2, Robert J Barry1,2

  • 1Academic Unit of Ophthalmology, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Ocular Immunology and Inflammation
|September 18, 2020
PubMed
Summary
This summary is machine-generated.

This study developed health utility values for birdshot chorioretinopathy (BCR) using Time Trade-Off (TTO) and Standard Gamble (SG) methods. Results indicate patient willingness to trade life years for improved vision, informing BCR management.

Keywords:
Birdshot chorioretinopathyEQ-5D-5LNEI VFQ-25quality of lifestandard gambletime trade-off

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Area of Science:

  • Ophthalmology
  • Health Economics
  • Patient-Reported Outcomes

Background:

  • Birdshot chorioretinopathy (BCR) is a rare, chronic inflammatory eye disease impacting vision.
  • Quantifying the health utility of BCR is crucial for treatment decisions and resource allocation.

Purpose of the Study:

  • To establish health utility values for patients with birdshot chorioretinopathy using Time Trade-Off (TTO) and Standard Gamble (SG) methodologies.
  • To assess the impact of BCR on patients' quality of life and their willingness to trade life for vision.

Main Methods:

  • 28 adult BCR patients completed TTO, SG, EQ-5D-5L, and NEI VFQ-25 questionnaires.
  • Clinical data including visual acuity were collected through detailed history and examination.

Main Results:

  • Mean TTO utility was 0.90 and mean SG utility was 0.94.
  • TTO utility demonstrated significant correlation with EQ-5D-5L index (p=.024) and NEI VFQ-25 composite score (p=.015).
  • 11 patients (39%) would trade a mean of 5.4 years of life for perfect vision; 6 patients (22%) would accept a mean 28% risk of immediate death for perfect vision.

Conclusions:

  • Health utility values derived from TTO and SG provide a quantitative measure of the burden of birdshot chorioretinopathy.
  • Patient preferences highlight a significant desire for improved vision, even at the cost of life years or risk.
  • These findings can inform clinical practice guidelines and health policy related to BCR management.