Choroidal Vascularity Index as a Potential Inflammatory Biomarker for Obsessive Compulsive Disorder
Berrak Sekeryapan Gediz1, Mehmet Ozturk2, Hilal Kilinc Hekimsoy1
1Ophthalmology Department, University of Health Sciences, Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Background:
To evaluate choroidal vascularity index (CVI) and to investigate the association of CVI with neutrophil-to-lymphocyte ratio (NLR) as an indicator of inflammation in obsessive-compulsive disorder (OCD).
Material And Methods:
This prospective study included newly diagnosed OCD patients and healthy controls. All patients underwent EDI-OCT imaging to assess the subfoveal choroidal thickness (sCT) and peripapillary CT (pCT). CVI was defined as the ratio of luminal area to stromal area after binarization on EDI-OCT images.
Results:
A total of 39 patients with OCD and 25 controls were included. The sCT, pCT, and CVI values were significantly higher in the OCD vs. control group (p˂0.05 for all). The NLR values were significantly higher in the OCD vs. control group (p = .007). A significant positive correlation was noted between CVI and NLR (p = .039).
Conclusion:
Our findings suggest that systemic inflammation may play a role in the pathogenesis of OCD.
