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Macrolide-Resistant Bordetella pertussis, Vietnam, 2016-2017.
Emerging Infectious Diseases
|September 18, 2020
Summary
Macrolide-resistant Bordetella pertussis strains, identified by the A2047G mutation in 23S rRNA, emerged in Vietnam. These resistant pertussis strains, including the MT104 genotype, were found in patients during 2016-2017.
Area of Science:
- Microbiology
- Genetics
- Infectious Diseases
Background:
- Macrolide resistance in Bordetella pertussis is a growing public health concern.
- The emergence of resistant strains necessitates ongoing surveillance and characterization.
Purpose of the Study:
- To investigate the genetic basis of macrolide resistance in Bordetella pertussis in Vietnam.
- To identify the specific mutations and genotypes associated with macrolide resistance.
Main Methods:
- Direct analysis of swab samples from pertussis patients.
- Identification of mutations in the 23S rRNA gene.
- Genotyping of Bordetella pertussis strains.
Main Results:
- A macrolide-resistant mutation, A2047G in the 23S rRNA gene, was detected in Bordetella pertussis.
- The MT104 genotype, prevalent in mainland China, and its variants were identified in Vietnamese patients.
- These findings indicate the presence of specific macrolide-resistant Bordetella pertussis strains.
Conclusions:
- Macrolide-resistant Bordetella pertussis strains have emerged in Vietnam.
- The identified A2047G mutation and MT104 genotype highlight potential transmission pathways and the need for targeted interventions.
Keywords:
23S rRNAA2047G mutationBordetella pertussisVietnamantimicrobial resistancebacteriagenotypingmacrolide resistancerespiratory infectionsMore Related Videos
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