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Updated: May 7, 2026

Alternative Cultures for Human Pluripotent Stem Cell Production, Maintenance, and Genetic Analysis
Published on: July 24, 2014
A Metabolic Bottleneck for Stem Cell Transformation
Sanjeethan C Baksh1, Elaine Fuchs1
1Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Abstract:
Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation.
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