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Meta-analysis of coagulation parameters associated with disease severity and poor prognosis of COVID-19

Aining Zhang1, Yan Leng1, Yi Zhang1

  • 1Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|September 18, 2020
PubMed

Insights

Abnormal blood coagulation, including D-dimer and fibrinogen levels, is linked to COVID-19 severity and mortality. These findings help identify high-risk patients for better COVID-19 management.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • COVID-19 (2019 Corona Virus Disease) has been associated with various clinical complications.
  • Understanding factors influencing COVID-19 severity and prognosis is crucial for patient management.

Purpose of the Study:

  • To investigate the association between abnormal coagulation parameters and COVID-19 disease severity.
  • To determine if coagulation abnormalities predict poor prognosis in COVID-19 patients.

Main Methods:

  • A systematic review and meta-analysis of 15 studies involving 2277 COVID-19 patients.
  • Analysis of coagulation parameters: Platelet count (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer (D-D), and fibrinogen (FIB).
  • Statistical analysis using mean difference (MD) and 95% confidence intervals (CI); publication bias assessed via funnel plot and Egger's regression.

Main Results:

  • Severe COVID-19 cases showed lower PLT and higher PT, D-D, and FIB compared to mild cases (P < 0.05).
  • ICU patients had significantly longer PT (P < 0.05).
  • Non-survivors exhibited higher PT and D-D, and lower PLT compared to survivors (P < 0.05). APTT showed no significant difference between groups.

Conclusions:

  • Coagulopathy is a significant risk factor for increased COVID-19 severity and mortality.
  • Abnormal coagulation parameters can aid clinicians in identifying COVID-19 patients at high risk of poor outcomes.
  • Monitoring coagulation status is essential for managing COVID-19 patients.
Abstract

Keywords:
COVID-19Coagulation parametersCoagulopathyLaboratoryPrognosis

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