Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: A meta-analysis

Area of Science:

• Genetics
• Immunology
• Gastroenterology

Background:

• Conflicting results exist regarding the association between IL12B gene polymorphisms (rs10045431 and rs6887695) and inflammatory bowel disease (IBD) risk in Caucasian populations.
• Previous studies have produced inconsistent findings, necessitating a comprehensive re-evaluation.

Purpose of the Study:

• To conduct a meta-analysis to provide more reliable conclusions on the association between IL12B rs10045431, rs6887695 polymorphisms and IBD risk.
• To clarify the genetic contribution of specific IL12B variants to IBD susceptibility in Caucasians.

Main Methods:

• A systematic literature search was performed across multiple databases (Wiley Online Library, PubMed, Web of Science, CNKI).
• Meta-analysis was employed to calculate odds ratios (OR) with 95% confidence intervals (CI).
• False positive report probabilities (FPRPs) and trial sequential analysis (TSA) were utilized to assess the reliability of the findings.

Main Results:

• The meta-analysis included 20 studies with a substantial number of cases and controls (10761 CD, 10921 UC, 18381 controls).
• IL12B rs6887695 polymorphism was found to significantly increase the risk for both Crohn's disease (CD) and ulcerative colitis (UC).
• Conversely, IL12B rs10045431 polymorphism was associated with a significant decrease in the risk for both CD and UC.
• FPRP and TSA confirmed the robustness of these observed associations.

Conclusions:

• The meta-analysis provides strong evidence that IL12B rs10045431 and rs6887695 polymorphisms are significantly associated with inflammatory bowel disease in the Caucasian population.
• These findings contribute to a better understanding of the genetic underpinnings of IBD and highlight specific IL12B variants as potential biomarkers.