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Inflammation in Obesity-Related Complications in Children: The Protective Effect of Diet and Its Potential Role as a
Valeria Calcaterra1,2, Corrado Regalbuto3, Debora Porri4
1Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
Insights
Pediatric obesity leads to inflammation and non-communicable diseases (NCDs). Early nutrition and lifestyle interventions are crucial for preventing obesity complications in children and adults.
Area of Science:
- Pediatrics
- Public Health
- Nutrition Science
Background:
- Obesity is a global health issue affecting children and adults, leading to significant physical and mental health impairments.
- Excessive weight gain is linked to numerous obesity-related complications, primarily Non-Communicable Diseases (NCDs) such as cardiovascular disease, type 2 diabetes, and hypertension.
- These NCDs are associated with chronic inflammation, reduced life expectancy, and increased healthcare costs worldwide.
Purpose of the Study:
- To review and discuss inflammatory complications associated with pediatric obesity.
- To highlight the essential role of nutrition and diet in preventing and managing obesity-related comorbidities.
- To examine the impact of lifestyle factors on pediatric obesity and its associated health issues.
Main Methods:
- This study is a review of existing literature on pediatric obesity, inflammation, and related comorbidities.
- It synthesizes information on the impact of diet, nutrition, and lifestyle interventions.
- The review focuses on evidence related to prevention and treatment strategies.
Main Results:
- Pediatric obesity is strongly associated with chronic inflammation, contributing to the development of NCDs.
- Nutritional status and dietary patterns significantly influence the risk and progression of obesity-related complications.
- Lifestyle modifications, including diet and physical activity, are vital for managing pediatric obesity and preventing long-term health consequences.
Conclusions:
- Early and appropriate dietary interventions are recommended for managing pediatric overweight and obesity.
- Proactive management is essential for promoting healthy growth and preventing adult-onset comorbidities.
- Addressing pediatric obesity through nutrition and lifestyle changes is critical for long-term public health outcomes.
Abstract:
Obesity is a growing health problem in both children and adults, impairing physical and mental state and impacting health care system costs in both developed and developing countries. It is well-known that individuals with excessive weight gain frequently develop obesity-related complications, which are mainly known as Non-Communicable Diseases (NCDs), including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, hypertension, hyperlipidemia and many other risk factors proven to be associated with chronic inflammation, causing disability and reduced life expectancy. This review aims to present and discuss complications related to inflammation in pediatric obesity, the critical role of nutrition and diet in obesity-comorbidity prevention and treatment, and the impact of lifestyle. Appropriate early dietary intervention for the management of pediatric overweight and obesity is recommended for overall healthy growth and prevention of comorbidities in adulthood.
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