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Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies

Arun Samidurai1, Anindita Das1

  • 1Division of Cardiology, Pauley Heart Center, Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

International Journal of Molecular Sciences
|September 19, 2020
PubMed

Insights

Coronavirus disease 2019 (COVID-19) causes severe cardiac impairment, including heart attacks and arrhythmias. This review highlights therapeutic approaches for cardiovascular complications in COVID-19 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents significant cardiovascular risks beyond respiratory symptoms.
  • Emerging evidence links COVID-19 to myocardial injury, heart failure, arrhythmias, and thromboembolic events, increasing adverse outcomes and mortality.
  • Pathophysiological mechanisms involve direct viral invasion, endothelial dysfunction, plaque destabilization, and hypoxic cardiac stress.

Purpose of the Study:

  • To provide a comprehensive review of integrated therapeutic strategies for COVID-19.
  • To summarize potential therapeutic options currently under clinical investigation for cardiovascular complications.
  • To detail mechanisms of action and associated cardiac adverse events of these therapies.

Main Methods:

  • Literature review of current research on COVID-19 and cardiovascular complications.
  • Analysis of ongoing clinical trials for therapeutic interventions.
  • Synthesis of information on pathophysiology, clinical manifestations, and treatment approaches.

Main Results:

  • COVID-19 is associated with diverse and severe cardiovascular complications, including myocardial infarction and myocarditis.
  • Multiple pathophysiological pathways contribute to cardiac impairment in COVID-19 patients.
  • Currently, no therapeutics have demonstrated proven clinical efficacy for cardiovascular complications in COVID-19.

Conclusions:

  • Understanding the interplay between COVID-19 and cardiovascular health is critical.
  • Further research and clinical trials are essential to identify effective treatments for COVID-19-related cardiac issues.
  • Integrated therapeutic approaches are needed to manage the complex cardiovascular manifestations of COVID-19.

Keywords:
COVID-19cardiovascular diseasestreatment strategies

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