Ionophore Use and Toxicosis in Cattle
1Anatomy & Physiology, Kansas State University, 1800 Denison Avenue, Mosier P217, Manhattan, KS 66506, USA.
The Veterinary Clinics of North America. Food Animal Practice
|September 19, 2020
Summary
Ionophore toxicosis in animals can occur from feed mis-mixing. Measuring cardiac troponins in serum offers a diagnostic method for this condition, even with delayed clinical signs.
Area of Science:
- Veterinary Toxicology
- Animal Nutrition
- Biochemistry
Background:
- Ionophores are common feed additives for animals, generally safe when used correctly.
- Accidental feed mis-mixing can lead to elevated ionophore doses, causing toxicosis.
- Myocardial and skeletal muscles are primary targets of ionophore toxicosis.
Purpose of the Study:
- To investigate diagnostic methods for ionophore toxicosis.
- To address challenges in diagnosing ionophore toxicosis due to delayed clinical signs and difficulty in obtaining feed samples.
Main Methods:
- The study focuses on the utility of serum cardiac troponins as a diagnostic biomarker.
- Evaluation of cardiac troponin levels in the context of suspected ionophore toxicosis.
Main Results:
- Cardiac troponins in serum can be effectively used for diagnosing ionophore toxicosis.
- This biomarker aids diagnosis despite the delay between toxic feed ingestion and symptom onset.
Conclusions:
- Serum cardiac troponins are a valuable tool for diagnosing ionophore toxicosis in animals.
- The use of cardiac troponins helps overcome diagnostic hurdles associated with delayed clinical presentation and feed sample collection.
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